Chelsea Firefighters were called to a house fire on Trinkle Road between Fletcher and Lima Center roads in Lima Township Thursday at about 11:30 a.m.
The two occupants in the home had to climb through a bedroom window to escape but were not injured.
Fire Capt. Colt White said there was significant fire and smoke to the single-story ranch home.
Firefighters from Dexter, Scio, the City of Ann Arbor, Manchester and Pittsfield township assisted on the scene.
He said the cause is still under investigation.